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Objective
Pursing the Post Doctoral in bioinformatics& Completed Masters with sound technical skills and good communication skills seeking an innovative and challenging opportunity that would facilitate mutual benefit of my employer and myself.
Highlights of Qualification
- Experienced in Computer aided drug designing, Gene therapy and worked with Senior Research analyst.
- Highly Motivated, goal Oriented professional; a decision maker skilled in implementing new ideas.
- A team player with strong communication, presentation, interpersonal and research skills
Professional Experience
1. Company Name- SAI’S BIOSCIENCE RESEARCH INSTITUTE (NOVEMBER- 2008 to June 2009)
Place- Chennai
Job Profile- Research analyst cum Faculty in Bioinformatics.
Description-
Worked with Senior Research analyst in designing Biomarker and Database on Molecular Biology for Gene and Protein Biomarker against several diseases like cancer.
- Designing of the new drug molecule.
- Molecular Docking Studies by using Commercial Software-ACCELRYS DS and ACCELRYS GENE
- ADME prediction.
- Well trained of various Bioinformatics tools and software.
Handled Various Project On-
Gene therapy: To knock down and silence the gene expression process of the mutated gene using Vector construction
Drug Designing: Studying and comparing the drug docking and interaction with the receptor.
Molecular Modeling: Protein modeling based on homology modeling and studying the importance of motif, domain and binding site region.
Microarray Data Analysis: Deals with giving a biological interpretation of the microarray data (spots) by constructing a tree that provides a correlation statistics of the microarray data.
Biostatistics: Applying (Statistical packages: SPSS, STATA etc) statistical principles on design, analysis of medical research data.
Guided Projects For Students & Verified Their Records:
· "An Insilco approach to target BRCA2 Gene using Antisense RNA"
· “Therapeutic- Vector Designing using Thyrosine phosphatase receptor- A target for RNA interference based therapy for Colorectal cancer.
· "Ribozyme mediated inactivation of ABCG5 gene in Sitosterolemia using recombinant vector"
· "Ribozyme mediated inactivation of SGCG gene in Dystrophy type2C syndrome using recombinant vector
· " De novo drug designing of drug like molecule against Maba (3-oxoacyl reductase) protein for tuberculosis"
2. College Name- NOORUL ISLAM COLLEGE OF ARTS & SCIENCE
(JULY-2009 to Present)
Place- Kumaracoil,Thuckalay
Job Profile- Lecturer in Bioinformatics
- Handling classes for UG & PG courses in Bioinformatics
- Handled the Practical classes for PG students in Bioinformatics
- Guided the Projects for UG, PG and M.Phil students in the area of Molecular fingerprint, Drug Designing and Gene therapy
- Handled Certificate course on “Perl for Bioinformatics” using Linux Platform for UG and PG students
- Taken the YSAP Classes for school students in NI Engineering college
- Trained the student’s activities in Seminar/ Conference/ Workshop programme.
Handling Various Classes On-
Molecular Modeling & Drug Design, Structural Bioinformatics, Computational Biology, Proteomics and Genomics, Metabolimics, Basics Bioinformatics Biocomputing & Biophysics
- Guided students for Various Project On
- UG Classes- "Molecular fingerprinting analysis on novel target protein Hemagglutinin from H1N1 Swineflu Virus- an In silico method"
- PG classes- "An Insilico approach to drug designing on novel target for tuberculosis caused by Mycobacterium tuberculosis"
Bioinformatics Skills:
R&D in Bioinformatics-
- Molecular modeling and docking
- Functional genomics
- Drug discovery and vaccine development
- Gene therapy
- Molecular Fingerprint analysis
- Microarray
Computing Skills:
- Programming languages: C,Shell
- Scripting Language: Perl and BioPerl
- OS: WINDOW'S XP, WINDOW'S NT AND LINUX
- DATABASE: SQL and ORACLE 9i
- Documentation tools: MS OFFICE 2000 (Word, Excel, Power point and Access)
Skilled Techniques:
- Virtual Screening
- Drug Designing (Structure based & Ligand based)
- Docking Analysis
- Protein- Ligand Interaction Studies
- Molecular Modeling
- Inter Residue Interactions.
- Therapeutic Vector Construction
- Vaccine development
- Comparative modeling
- Perl programming & Web Designing
Mol-Bio
- Cell culture techniques: Cell isolations, Purification and maintaining cells under lab conditions etc.
- Sterilization technique-Centrifugation, Chromatography, Electrophesis, PCR, MARKER STUDY
- Ligation method DNA isolation methodologies, Isolation of plasmid.
Short Term Courses
- Successfully completed the Course on Remedial Mathematics
- Hand on experience in PERL programming under the guidance of Ajanta Devi (Infosys), Sri Ramachandra University, Chennai
- Trained on a mini integrated project on the Microarray data analysis of psoriasis at Sri Ramachandra University, Chennai
Academic Training
- One day visit to the Sankara Netralaya, Chennai, India. During visit we have been exposed to the techniques like Real Time PCR, Microarray and Automated DNA sequencing.
M.sc Projects undergone:
Project-I
- Project Name :“A PHYLOGENETIC ANALYSIS ON ECDYSTEROID RECEPTOR OF ARTHROPODS AND OTHER INVERTEBRATES USING NOVEL METHODS”
- S/W : NCBI, CLUSTAL W,PHYLIP, TREE-PUZZLE,TREE-VIEW, MEGA
- Platform : Windows 2000/XP
- Place - National Institute of Ocean Technology (Ministry Of Earth Sciences, Govt. Of India),Chennai
Project-II
- Project Name : INSILICO MOLECULAR MODELLING & DOCKING STUDIES
- S/W : DISCOVER, AFFINITY, LUDI, ANALYSES AND QSAR.
- Platform :Linux
- Place - Sri Ramachandra University,Chennai.
Research papers
- Published a research paper in KAAS - .”Insilico Homology modeling and Drug designing of PerfringolysinO from Clostridium perfringeni” Dec,2009 at Hindu college, Nagercoil, India
Paper Presentation
- Presented a paper on Global warming at National Seminar on Human Values & the Emerging Problems of Science & Techn. Developments on Nuclear Hazards, August 2005, Sarah Tucker College, Tirunelveli.
- Presented the paper- Prediction of antigenic determinant of proteins at National Symposium on "Prospective aspects of Microbial diversity”, July, 2009, at Standard Fireworks Rajaratnam College for Women, Sivakasi, , India
- Presented the papers at National Symposium on "Zavest-09” Aug,2009, Satyabama University, Chennai, India
a. A phylogenetic analysis of ecdysteroid receptors of arthropods and other invertebrates
b. Comparative gene analysis of hereditary and non-hereditary genes of Prostate cancer.
- Presented a paper- Insilico Homology modeling and Drug designing of PerfringolysinO from Clostridium perfringeni”, Dec 2009, Hindu college, Nagercoil, India
- Presented the papers at Technical frontiersSymposium on BioQuest "Noorul Islam College of Arts and science, Kumaracoil, Thuckalay.
a. A phylogenetic analysis of ecdysteroid receptors of arthropods and other invertebrates
b. An Insilico approach to Drug Designining on novel target for leprosy caused by Mycobacterium Leprosy
Poster Presentation
- Presented the following posters at National Symposium on "Zavest-09” Aug,2009,
Satyabama University, Chennai, India
a Drug Target Identification on Anthrax using SBDD
b. Bioinformatics in Immunoinformatics
Seminar/ Workshop Attended
- January 2010- Attended the Biotrix association for Biosciences, Noorul Islam College of Arts and science, Kumaracoil, Thuckalay.
- December 2009- KAAS publication for research papers at Hindu college, Nagercoil, India
- August 2009- National Symposium on "Zavest-09” Satyabama University, Chennai, India
- July 2009- National Symposium on "Prospective aspects of Microbial diversity”, July, 2009, at Standard Fireworks Rajaratnam College for Women, Sivakasi, , India
- February 2007 -National Workshop on Matlab in Bioinformatics by Dept of Bioinformatics at Sri Ramachandra University ,Chennai
- August 2007 - National Workshop on Molecular Modeling & Drug Design at
- Sri Ramachandra University, Chennai.
- February 2007 - First National Workshop on Microarray Data Analysis, Sri Ramachandra University, Chennai
- August 2005 - National Seminar on Human Values & the Emerging Problems of Science & Techn. Developments on Nuclear Hazards, Sarah Tucker College, Tirunelveli.
- September 2005 - Seminar Cum Workshop on Molecular Trends in Microbiology, V.H.N.S.N.College, Virudhunagar.
- February 2005- Seminar Cum Workshop on Emerging Trends in Microbiology,V.H.N.S.N.College,Virudhunagar.
- July 2004-Department of Microbiology & International Centre For Bio-Resources Management (ICBM), Seminar on Recent Trends in Microbiology, Malankara Catholic College, Kaliakkavilai
Visiting Faculty
Guest Lecturer – (Sri Ramachandra University, Chennai)
Achievement
UNIVERSITY RANK HOLDER (Manonmaniam Sundaranar University,)
PUBLISHED M.SC PROJECT WORK in MBiC web site @ NIOT, Central gov.of India
Launched my own website
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"Here is some of the Bioinformatics Resources on the Internet"
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